SM-102 - Wikipedia
SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2] [3] [4] and in particular SM-102 forms part of the drug delivery system for …
Effect of mRNA-LNP components of two globally-marketed COVID …
2023年10月11日 · We found that SM-102 ionizable lipid outperforms ALC-0315 in intramuscular delivery of mRNA, displayed by higher luciferase expression, as well as LNP stability in vitro when stored at 4 °C.
The Moderna vaccine contains SM-102 not chloroform - Full Fact
2021年5月25日 · SM-102 is a lipid molecule used to form the nanoparticle which carries the mRNA in the Moderna vaccine to cells in the body. The Pfizer vaccine uses different lipid molecules for this purpose. Although SM-102 is used in the Moderna vaccine, the vaccine does not contain chloroform and it is not listed in the vaccine’s ingredients.
Fact Check: SM-102 lipid in Moderna COVID-19 vaccine is not …
2021年5月27日 · The safety fact sheet that social media users are sharing as alleged proof of the harmful nature of the lipid SM-102 in the Moderna COVID-19 vaccine, is actually describing the dangers of...
Reformulating lipid nanoparticles for organ-targeted mRNA
2024年7月5日 · Here, we reformulate lipid nanoparticles (LNPs) through adjustments in lipid material structures and compositions to systematically achieve the pulmonary and hepatic (respectively) targeted mRNA...
mRNA Vaccines Against SARS‐CoV‐2 Variants Delivered by Lipid ...
2022年7月19日 · Head-to-head comparisons of 4N4T lipids and SM-102 showed that 4N4T-DS mRNA vaccines based on MIC1 and MIC2 had higher delivery efficiency and triggered a more robust and durable immune response against variants of …
In vitro and in vivo evaluation of clinically-approved ionizable ...
2023年9月1日 · In the present study, we examined the effects of the three clinically-approved ICLs, Dlin-MC3-DMA, ALC-0315 and SM-102, as well as DODAP, on the in vitro and in vivo performance of LNPs for mRNA delivery and vaccine efficacy. mRNA-LNPs containing these lipids were successfully prepared, which were all found to be very similar in their ...
Vaccine Ingredient SM-102 Is Safe - FactCheck.org
2021年5月26日 · All of the videos and posts focus on the same ingredient, though — SM-102, which is a lipid, a fatty molecule that doesn’t dissolve in water. We’ll explain more about it below.
An ionizable lipid toolbox for RNA delivery - Nature
2021年12月13日 · When reviewing the approved MC3, SM-102, and ALC-0315 structures as well as those patented by Acuitas et al. 46,47,48,50, the ester-based biodegradable structure appears in every ionizable...
You asked, we answered: Is it safe for SM-102 to be in the …
2021年5月21日 · Yes, the Moderna COVID-19 vaccine does contain SM-102. And yes, the vaccine is safe. SM-102 is a lipid molecule. (A lipid molecule is a molecule that does not dissolve in water.) The molecule helps form the lipid nanoparticles in the Moderna vaccine. (A lipid nanoparticle is an extremely small amount of matter that doesn’t dissolve in water.)