Formation and migration of neural crest cells in the ...
After neural tube closure, neural crest cells depart from the dorsal CNS via an epithelial to mesenchymal transition (EMT), forming a migratory mesenchymal cell type that migrates extensive to diverse locations in the embryo.
Neural Crest Cell Migration: Guidance, Pathways, and Cell ...
2014年1月1日 · NCC start their migration by separating from the neuroepithelium. This process, called delamination, involves an epithelium-to-mesenchyme transition (EMT). NCC migration is then controlled by a large array of inhibitors, permissive factors, and positive guidance cues as well as cell–cell interactions.
Neural Crest Delamination and Migration: Integrating ...
During migration, neural crest cells may face hostile environments that may repulse them or cause their death, but they may also occupy more accessible areas where they survive, grow and sometimes settle to undergo differentiation.
Mechanisms of Neural Crest Migration - PubMed
2018年11月23日 · During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells' migration.
Neurogenesis From Neural Crest Cells: Molecular Mechanisms …
Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well as non-neural cells.
The road best traveled: Neural crest migration upon the ...
The ECM has diverse functions for governing neural crest cell migration, and reciprocal interactions between neural crest cells and the ECM are required for proper delamination and migration of neural crest cells throughout the embryo.
Neural crest migration: trailblazing ahead - PMC
2015年1月5日 · After emerging from the dorsal neural tube in a head-to-tail order, neural crest cells begin their journey by entering diverse microenvironments rich in extracellular matrix (ECM) and other cell types.