CAR T cell - Wikipedia
In biology, chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that have been engineered to give T cells the new ability to target a specific antigen.
An introduction to chimeric antigen receptor (CAR) T-cell ... - PubMed
Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
Chimeric Antigen Receptor T-Cell Therapy - StatPearls - NCBI Bookshelf
2022年10月3日 · Chimeric antigen receptors usually contain an extracellular domain that binds to a specific antigen on tumor cells, a transmembrane domain, and intracellular domains that signal T-cell activation to attack tumor cells.
The basic principles of chimeric antigen receptor (CAR) design
Chimeric antigen receptors (CARs) are a new class of drugs with great potential for cancer immunotherapy. Upon their expression in T lymphocytes, CARs direct potent, targeted immune responses that have recently shown encouraging clinical outcomes in a subset of patients with B cell malignancies.
CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
2022年3月10日 · They are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs. The CARs recognize and bind to specific proteins, or antigens, on the surface of cancer cells.
Chimeric Antigen Receptor - an overview | ScienceDirect Topics
Chimeric antigen receptors (CARs) are fusion proteins where the binding site of a monoclonal antibody (Ab) is fused to intracellular signaling molecules. Upon engraftment in T cells, CARs direct their antigen-specificity toward antigens expressed on the cell surface of tumor cells.
Engineering and Design of Chimeric Antigen Receptors - PMC
T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers. Since the first clinical reports of their efficacy emerged 7 years ago, ...
Chimeric Antigen Receptor (CAR) T-Cell Therapy
After this reengineering, the T cells are known as “chimeric antigen receptor (CAR) T cells.” CARs are proteins that allow the T cells to recognize an antigen on targeted tumor cells. The reengineered CAR T cells are then multiplied.
Chimeric Antigen Receptor - an overview | ScienceDirect Topics
Chimeric antigen receptors (CAR) are synthetic receptors that combine an antigen-specific extracellular domain, usually derived from the variable regions of an antibody, with the key functional intracellular domains of a T cell receptor (TCR).
Chimeric antigen receptor-T cell therapy for T cell-derived ...
2024年11月28日 · Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived malignancies. However, the treatment of CAR-T cells in T cell-derived malignancies has more limitations, such as fratricide, T cell aplasia, and tumor contamination, mainly because of the similarity between normal ...