Calbindin - Wikipedia
Calbindin contains 4 active calcium-binding domains, and 2 modified domains that have lost their calcium-binding capacity. Calbindin acts as a calcium buffer and calcium sensor and can hold four Ca 2+ in the EF-hands of loops EF1, EF3, EF4 and EF5.
Calbindin - an overview | ScienceDirect Topics
Calbindin is a calcium-binding protein found in certain neurons of the central nervous system. Its main role is to regulate the levels of intracellular calcium, which is crucial for the survival of neurons. It is also influenced by steroid hormones, including adrenal corticosteroids.
CALB1 Gene - GeneCards | CALB1 Protein | CALB1 Antibody
2024年10月1日 · CALB1 (Calbindin 1) is a Protein Coding gene. Diseases associated with CALB1 include Blessig's Cysts and Temporal Lobe Epilepsy. Among its related pathways are Metabolism of proteins and RNA Polymerase I Promoter Opening. Gene Ontology (GO) annotations related to this gene include calcium ion binding and vitamin D binding.
Calbindin - an overview | ScienceDirect Topics
Calbindin (also called cholecalcin, or vitamin D-dependent calcium-binding protein) is a vitamin D-dependent protein that binds calcium with high affinity (the calcium-binding regions are homologous to those of the calmodulin family), constituting approximately 2% of duodenal mucosal cell protein (found only in high amounts in the duodenum) in ...
Calcium-Binding Proteins as Determinants of Central Nervous …
Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis.
Crucial role of calbindin-D28k in the pathogenesis of Alzheimer’s ...
2014年5月23日 · Calbindin-D 28k (CB), one of the major calcium-binding and buffering proteins, has a critical role in preventing a neuronal death as well as maintaining calcium homeostasis.
Calbindin - an overview | ScienceDirect Topics
Calbindin, a 28kD protein with a Ca2+ binding domain, was discovered in peripheral tissues (e.g., intestine and kidney), but has emerged as an interesting molecular marker in brain. For now, ‘marker’ may be the best term, as the exact function (s) of calbindin remain unclear.
Calbindin regulates Kv4.1 trafficking and excitability in dentate ...
2021年7月7日 · Calbindin, a major Ca 2+ buffer in dentate granule cells (GCs), plays a critical role in shaping Ca 2+ signals, yet how it regulates neuronal function remains largely unknown.
Calbindin 1 - Wikipedia
Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). [5]
Biological actions and mechanism of action of calbindin in the ... - PubMed
Calbindin was found to block apoptosis in osteocytic and osteoblastic cells. Our findings suggest that calbindin is capable of directly inhibiting the activity of caspase-3, a common downstream effector of multiple apoptotic signaling pathways, and that this inhibition results in an inhibition of tumor necrosis factor (TNFalpha) and ...