An overview of the c-MET signaling pathway - PMC
c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.
C-Met - an overview | ScienceDirect Topics
Hepatocyte growth factor/scatter factor is a pleiotropic cytokine and induces cellular transformation and cell migration of tumor cells when binding to a tyrosine kinase receptor MET encoded by the C-Met protooncogene.
Structural basis of the activation of c-MET receptor
2021年7月1日 · Aberrant activation of c-MET can lead to both tumors growth and metastatic progression of cancer cells. C-MET can be activated by either hepatocyte growth factor (HGF), or its natural...
Function of the c-Met receptor tyrosine kinase in carcinogenesis …
2018年2月19日 · In this review, we elaborate on the molecular structure of c-Met and HGF and the mechanism through which their interaction activates the PI3K/AKT, Ras/MAPK, and Wnt signaling pathways. We also summarize the connection between c-Met and RON and EGFR, which are also receptor tyrosine kinases.
Discovery of novel exceptionally potent and orally active c-MET …
The mechanisms of aberrant activation of the c-MET pathway mainly include MET gene amplification, protein overexpression, and MET exon-14 skipping (METex14) mutation. c-MET overexpression or MET gene amplification is commonly detected in multiple solid tumors.
C-Met - an overview | ScienceDirect Topics
2010年3月2日 · C-Met protein is a transmembrane tyrosine kinase that binds the hepatic growth factor (HGF) and plays an important role in the ability to metastasize. C-Met is demonstrated in carcinomas, mesotheliomas, and sarcomas and is also shown to have prognostic significance.
Hepatocyte growth factor receptor - Wikipedia
Since HGF is the only known ligand of MET, blocking the formation of a HGF:MET complex blocks MET biological activity. For this purpose, truncated HGF, anti-HGF neutralizing antibodies, and an uncleavable form of HGF have been utilized so far.
An overview of the c-MET signaling pathway - SAGE Journals
2011年11月1日 · c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.
Safety and Tolerability of c-MET Inhibitors in Cancer - PMC
The role of aberrant hepatocyte growth factor receptor (c-MET, also known as tyrosine-protein kinase MET)/hepatocyte growth factor (HGF) signaling in cancer progression and invasion has been extensively studied. c-MET inhibitors have shown promising ...
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth
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