Polyol pathway - Wikipedia
The polyol pathway is a two-step process that converts glucose to fructose. [1] In this pathway glucose is reduced to sorbitol, which is subsequently oxidized to fructose. It is also called the …
Biochemistry, Polyol Or Sorbitol Pathways - StatPearls - NCBI ...
2022年11月14日 · The sorbitol or polyol pathway is a two-step metabolic pathway that converts glucose into fructose. This pathway is thought to play a prominent role in explaining the …
Polyol Pathway - an overview | ScienceDirect Topics
The polyol pathway is a two-step metabolic pathway wherein the enzyme aldose reductase utilizes NADPH to reduce glucose to sorbitol, which is then converted to fructose by the …
Polyol Pathway - an overview | ScienceDirect Topics
The polyol pathway was the first pathway explored to understand the underlying relationship between hyperglycaemia to the microvasculature. It is a two-step process that converts …
Redox imbalance stress in diabetes mellitus: Role of the ...
In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …
Polyol Pathway - an overview | ScienceDirect Topics
Polyol pathway and associated metabolic derangements. Activation of the polyol pathway is an early abnormality in DPN. It comprises two steps: the conversion of glucose to sorbitol by …
Oxidative stress and diabetic complications - PMC
The polyol pathway is based on a family of aldo-keto reductase enzymes which can utilize as substrates a wide variety of carbonyl compounds, and reduce these by nicotinic acid adenine …
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