Aging Cell - Wiley Online Library
2011年9月5日 · Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, …
Hallmarks of aging: An expanding universe - Cell Press
2023年1月3日 · We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated …
Cellular senescence in ageing: from mechanisms to therapeutic ... - Nature
2020年12月16日 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been …
The cell biology of aging - PMC - PubMed Central (PMC)
Major features of cellular aging. As the cell ages, translational defects and entropy progressively increase the amount of cellular damage, and clearance and quality control mechanisms grow …
Senescence and aging: Causes, consequences, and therapeutic …
Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal …
Molecular mechanisms of aging and anti-aging strategies | Cell ...
2024年5月24日 · Aging is a complex result of many biological processes, and many key factors trigger aging, such as DNA damage, telomere dysregulation, mitochondrial dysregulation, …
The role of senescent cells in ageing - PMC - PubMed Central (PMC)
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to …
The Hallmarks of Aging - Cell Press
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major …
The central role of DNA damage in the ageing process | Nature
2021年4月28日 · Phenotypically, the ageing process is associated with a wide variety of features at the molecular, cellular and physiological level—for example, genomic and epigenomic …
Aging and aging-related diseases: from molecular mechanisms to …
2022年12月16日 · Cellular senescence, with major effects on the maintenance of normal tissue homeostasis, as well as pathological conditions, is a principle causative factor in the …
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