Here, we demonstrated that ozone, as an emerging therapeutic approach, could effectively treat NPP by promoting macrophage efferocytosis, reducing the accumulation of apoptotic cells and suppressing ...

Efferocytosis, the phagocytic clearance of dying cells by phagocytes, especially microglia and macrophages, plays a critical role in this resolution process. Upon tissue injury, phagocytes are ...

recent studies implicate that Zn2+ influx into monocytes regulated by ZIP8 is a novel factor determining their adhesion and recruitment to atherosclerotic lesions. The potential role of ZIP8 in ...

We found that the patients’ ACK1 and BRK variants impair efferocytosis, the MERTK-mediated anti-inflammatory response to apoptotic cells, in human induced Pluripotent Stem Cell (hiPSC)-derived ...

Cells of the mononuclear phagocytic lineage differentiate into many different types of macrophage with a wide range of activities. These include specialized types of macrophage, such as Kupffer ...

(CARM) presented promising preclinical data on engineered macrophages for treating liver ... disease with factors including TIM4 (restores efferocytosis), relaxin (inhibits hepatic stellate ...

Neutrophils, monocytes and macrophages arise from common precursors, explaining much of their functional and phenotypical overlap. However, these cells also have complementary functions during the ...

9Experimental and Translational Pathology Platform, AMMICa, INSERM US23/UAR3655, Gustave Roussy, Villejuif, France. 20Department of Pathology, University Paris-Saclay, Gustave Roussy Cancer Center, ...

Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.