Genetic engineering technologies allow for the creation of custom-made cells that can have transformative effects on human health. This is best exemplified by chimeric antigen receptor (CAR ...

Larotrectinib for Newly Diagnosed Infantile Fibrosarcoma and Other Pediatric NTRK Fusion–Positive Solid Tumors (Children's Oncology Group ADVL1823) Sixteen patients were treated, with a median of four ...

A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed ...

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in ...

The new findings and immunotherapeutic strategies, which were published in Cell Metabolism, could be used to make multiple types of T-cell therapies more effective for patients, possibly ...

As well as causing lower body weight and improved metabolism ... have genetically modified T-cells into CAR (chimeric antigen receptor) T cells, to attack senescent cells. They used this treatment ...

most famously the chimeric antigen receptors used in CAR-T cell cancer therapy. But existing synthetic receptors are limited in the variety of keys they can accept and the activities they can trigger.

More information: Macarena Román Alonso et al, Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors, Nature Communications (2024). DOI: 10.1038/s41467-024-53265-7 ...

Image Credit: Nemes Laszlo / Shutterstock In a recent study published in the journal Nature Biotechnology, a group of authors explored recent advances in Chimeric antigen receptor (CAR ...

Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell therapy, obecabtagene ...