Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders ...

Deep in a tumor, full of rapidly dividing cells, cancer cells are faced with a lack of oxygen, a condition called hypoxia.

lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

These cells inhibit antitumor immunity while increasing tumor growth. The hypoxic response pathway Cells respond to low oxygen levels through stabilization of the HIF1/2α transcription factors.

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their ...

The hypoxia-inducible factor HIF promotes the transcription of angiogenesis-related factors.

Robert J. Griffin, professor of radiation biology at UAMS, will discuss possible routes to avoid or exploit tumor hypoxia for specific drug actions in cancer treatment at 12:55 p.m. Wednesday in Bell ...

Glioblastoma multiforme (GBM) is the most lethal primary adult brain cancer. Genomic instability, angiogenesis or chronic ...

Hepatocellular carcinoma (HCC) stands as the dominant form of liver cancer, ranking as the fourth leading cause of cancer-related deaths globally.